

& Magda Linette (40) → replaced by Margarita Gasparyan (LL).& Amanda Anisimova (30) → replaced by Ysaline Bonaventure (LL).& Kiki Bertens (9) → replaced by Aliona Bolsova (103).Taylor Townsend (89) → replaced by Andrea Petkovic (102).Carla Suárez Navarro (83) → replaced by Mona Barthel (101 PR).Veronika Kudermetova (third round)Ĭlick on the seed number of a player to go to their draw section. Williams announced her retirement from professional tennis the following year.Ġ 1. This was the seven-time champion's final appearance at the event. Serena Williams equaled Chris Evert's all-time record of 54 major quarterfinals at this tournament she then lost to Osaka in the semifinals. At 35 years of age, Hsieh also became the oldest player to make her quarterfinal debut. Hsieh Su-wei became the first Taiwanese woman to make a major singles quarterfinal. Mayar Sherif became the first Egyptian woman to win a major main draw match. Venus Williams became the first player aged 40 or more to win her first-round match since Martina Navratilova at the 2004 Wimbledon Championships.

Sofia Kenin was the defending champion, but lost to Kaia Kanepi in the second round. Osaka became the third player in the Open Era, after Monica Seles and Roger Federer, to win their first four major finals.

She only lost one set during the tournament, to Garbiñe Muguruza in the fourth round she also saved two match points in that match, making her the eighth woman to win the Australian Open after saving match points. With the win, Osaka extended her winning streak to 21 matches, dating to the 2020 Cincinnati Open. It was her second Australian Open title and fourth major title overall. Naomi Osaka defeated Jennifer Brady in the final, 6–4, 6–3 to win the women's singles tennis title at the 2021 Australian Open.
